This research aims to determine the effect of competence, work environment and motivation on employee performance. There are three variables in this study, namely Competence, Work Environment and Motivation as independent variables and employee performance as the dependent variable. This research was conducted with descriptive verification method, the population used were all employees of Utama Clinic in Bandung, while the sample in this study found 105 employees of Main Clinic in Bandung. The data used in this study were obtained by distributing questionnaires. Analysis of the data in this study using the method of Multiple Regression Analysis, analysis of determination and research hypotheses using t-test and F-test. The results of the research descriptively explain that the variables of competence, work environment, motivation and employee performance are in the fairly good category but there are indicators whose assessments are still low in each. The results showed that competence, work environment and motivation had a positive and significant influence on employee performance. Simultaneously shows that competence, work environment and motivation have an influence of 81,9% and the rest is explained by other factors not examined.