This study aims to analyze the development of microeconomics variables such as Debt to Equity Ratio (DER) and earning per share (EPS); macroeconomics variables such as interest rate and exchange rate; and the stock price of PT. Mayora Indah, Tbk and examine the influence both microeconomics and macroeconomics variables to the stock price. The method used are descriptive and verifikatif methods. The data used are secondary data from PT. Mayora Indah, Tbk’s annual reports with period of 2011-2016. The design of hypothesis testing using multiple linear regression analysis, t-test analysis and f-test analysis. The results of this study indicate that partially DER, interest rate, and exchange rate have no effect to the stock price. But EPS has significant effect to the stock price. The simultaneously results of Debt to Equity Ratio (DER), Earning Per Share (EPS), interest rate, and exchange rate (USD/IDR) have a significant effect to the stock prices. The magnitude of correlation coefficient is 75,2% which means it has a strong relationship, as well as the coefficient of determination of 56,5%, which means 43,5% influenced by other factors not examined.